Contract Research Organisations

Acumen
Acumen is dedicated to the early development of medicines and has a rapidly growing reputation as an innovative phase I/III contract research organisation.	The high quality, flexible and fully integrated clinical development services have been developed to assist clients with accelerated start up and rapid development of their drug development lifecycle.	Acumen is a team of fully trained, dynamic and flexible clinical research professionals, physicians, research nurses and project managers with a strong work ethic, who are widely respected and experienced in all aspects of pharmaceutical contract research.
The clinical research unit provides excellent facilities for both short and long-term residence; this together with our careful screening selection procedures ensures that we have an enviable reputation for patient and healthy volunteers successfully completing studies.	Acumen has also actively recruited patients for multicentre phase III clinical trials, acting as a central site and often aided in the rapid recruitment/conduct of patient studies in collaboration with other larger contract research organisations.

Adesis
Adesis is a multi-dimensional contract research organization (CRO) specialising in organic synthesis, for milligrams to kilogram quantities, for the life sciences and biomaterials industry.	Outsourcing should be a strategic component of any sponsor’s research and development portfolio, instead of an ad hoc decision.	In medicinal chemistry, this strategy allows in-house chemists to focus on the design and assembly of new lead molecules versus routine syntheses which can be outsourced.
Full time equivalents (FTE’s) are committed full time to the sponsor. FTE-based projects are quoted on time and materials, with back-charge of raw materials.	One-off projects are typically more traditional Kilo Lab projects involving large quantities of material.

Almac
Almac Sciences is involved in many activities including milligram to multi tonne synthesis, and synthesis of potent and cytotoxic compounds.	Almac Clinical Technologies provide Interactive Voice and Web Response Systems (IXRS™ ) for patient tracking - patient randomisation includes centralised randomisation, stratified randomisation and adaptive / balancing algorithms.	Almac Clinical Services provides a global service for the manufacture, packaging and distribution of clinical supplies.
Almac Diagnostics provide a generation of novel disgnostic products to improve patient management.

ALS Scandinavia
The purpose-built ALS laboratory in Luleå, Sweden, houses eight HR-ICP-MS instruments.	Trace metal monitoring is performed under cleanroom conditions.	HR-ICP-MS instruments offer detection at low ppt levels.
Our chemists perform research focused on clinical applications and isotopes.

Animascope
Non-invasive imaging allows the visualisation of structures, functions and dysfunctions in the whole body, for research purposes.	Animascope has a robust expertise in studies on physiopathology of bones and bones metastasis.	At Animascope, expertise and access to medical imaging technologies are readily available, such as for studies of reproductive medicine.
Animascope is a specialist in non-invasive 3D-imaging techniques such as X-ray computed tomography (CT) for studies of hard and soft tissues.	Whole-body multimodality studies can be performed on healthy and disease animal models, in many species. (Image courtesy of Siemens Molecular Imaging.)

ARTES Biotechnology
The Hansenula expression system offered by ARTES strikes with high yield, high robustness and high reliability resulting in cost-efficient production processes.	Lab-scale process development for technology transfer to manufacturing sites.	Documentation for registration purposes.

BEBAC
BEBAC specialises in providing biostatistical services, contractor selection and supervision.	We are able to support our clients both in the planning stage and in the evaluation of studies, responding deficiency letters, as well as preparation for regulatory hearings, placement and evaluation of CROs.

Biomodels
Biomodels provides pre-clinical efficacy studies for drug development.	We have particular expertise in cancer supportive care and pre-clinical models relating to the side effects of chemotherapy and radiation treatments.	We provide customized programs to demonstrate efficacy data (non-GLP) for regulatory submissions.
Endoscopy - normal colon.	Endoscopy - IBD colon.

Biovays
Healthy human colon epithelium – merge of three labellings.	Mouse small intestine showing labelled Paneth cell secretory granules; optical microscope image of specific Phloxine-tartrazine labelling on a paraffin-embedded section of the intestinal crypts or Lieberkühn glands.	Human vascular endothelial cells 24h after TNFalpha-induced inflammation phalloidin-TRITC and ICAM-1 labelling.
Thanks to our partnership with Olympus France our imaging platform is equipped with ground-breaking biological imaging equipment: next generation HD microscopy, image acquisition and support technologies.	Biomarker solutions for drug success: quantification of the effects of active biological agents on different cellular targets in human and animal tissue as well as cell culture.

Biovian
Biovian is a one-stop-shop that provides cGMP contract manufacturing of biopharmaceuticals.	We offer a wide range of services from early development to aseptic fill and finish.	Biovian’s cGMP facilities and state-of-the-art equipment enable flexible pilot production and development services.
Biovian’s 1,600m² cGMP facilities contain EU grade A, B, C and D class clean rooms and warehouses under full quality control, as well as extensively equipped development laboratories.	Biovian offers aseptic filling and finishing services.

Cerebricon
Cerebricon has its own scientists, preclinical laboratories and animal facilities for CNS drug development; this includes a 7.0 Tesla MRI for small animal imaging including pharmacological MRI (phMRI) for use with in vivo, in vitro and ex vivo models of CNS and PNS disease.	Pharmacological MRI (phMRI) is a new method used for the noninvasive preclinical study of drugs aimed at CNS diseases like Alzheimer’s, Parkinson’s and stroke; it is also used for the study of psychiatric diseases. Here we see the in vivo signal created by the iv introduction of nicotine by a specific area in the cortex of the brain.	Cerebricon’s laboratories are fully equipped to run multiple studies in parallel, while Cerebricon’s internal quality assurance programme ensures that studies and results adhere to the highest possible standards; where possible Cerebricon studies are automated. Cerebricon can run preclinical rodent studies with small numbers of animals all the way up to very large cohorts.
The ability of a CNS CRO to provide behavioural modelling and the most pertinent transgenic model, as well as imaging and histological services all under one roof, is very important. Here we see a close up of amyloid beta plaques from the hippocampus of a transgenic (TG2576) mouse; this was done with immunohistochemical detection in Cerebricon’s laboratories.	Cerebricon’s in vitro cell laboratories carry out many studies involving primary cortical neurons and also neurite outgrowth assays (NOG); in this picture we see the mitochondria of cortical neurons (orange areas) stained with Mitotracker.

ETS Nederland
High quality monitoring of non-clinical studies.	Nonclinical drug development services in safe hands.	En route to novel medicines.
Henk Tennekes provides toxicology and nonclinical drug development services that you can rely on.	Henk Tennekes' considerable experience in toxicology enables him to provide high-quality nonclinical drug development services and toxicology consultancy services.

Exploristics
Exploristics provides a clinical data analysis service.	We use a broad range of tools for clinical data exploration, mining and modelling.	We are experts in the clinical application of biomarkers and pharmacogenomics data.
We supply and distribute biomarker data management, visualisation and analysis tools in Europe.

ikfe CRO
ikfe CRO is an international service provider in the area of clinical contract research.	Core competences: consulting, organisation and conduct of multinational clinical research projects.	Our main focus is the chronic metabolic disorder of diabetes mellitus.
We can offer you comprehensive and ethics-committee-reviewed GCP training to ensure the qualification of your study site.

Institut Kuhlmann
We address customer specific analytical questions for analytical services for pharmaceutical quality control.	We are your competent partner for all enquiries about analytical services for pharmaceutical quality control.	Amino acid analysis according to the Ph Eur is a complex procedure requiring long experience.
For vitamin analysis we exclusively use chromatographic and mass spectrometric methods.	Structure elucidation of unknown impurities requires a multi-step approach.

InSymbiosis
From first discussions with a client through to the achievement of project deliverables, InSymbiosis' proven project management process ensures projects are executed and delivered on time and on budget and at the highest scientific standards.	InSymbiosis’ drug discovery services cover the complete discovery process, from validation of a drug target through to optimization of a lead compound.	At InSymbiosis, our substantial experience in preclinical chemical optimization and chemistry, manufacturing and control (CMC) can facilitate our clients’ transition through lead optimization to the development and optimization of a clinical candidate.
InSymbiosis is able to provide GLP-compliant toxicology and safety pharmacology services, including the management and monitoring of these important studies.	Working in symbiosis towards your therapeutic goals, our team of experts will accelerate your progress and compliment your core strengths; InSymbiosis: your first choice in partner.

Kemwell
Kemwell has extensive expertise in contract manufacturing and development services for pharmaceutical products.	The staff at Kemwell’s pharmaceutical development labs have developed formulations and analytical methods for conventional and specialised dosage forms.	We offer formulation and process development, development and validation of analytical methods, clinical supply, scale-up, process validation, and stability studies.
In partnership with a leading pharmaceutical company Kemwell has set up an oral healthcare R&D centre.	Our development services include EU gateway release testing, stability studies, and transfer of analytical methods.

Marin Biologic Laboratories
Marin Biologic Laboratories is a contract research organization (CRO) that provides custom research and development as well as GLP and GMP compliant assay development, validation and testing services for the pharmaceutical, biotechnology, diagnostic and agricultural industries.	What distinguishes Marin Biologic from other contract laboratories is a breadth of scientific knowledge, our client communication and our flexibility.	We blend the fields of cell biology immunology, molecular biology and biochemistry to tackle complex projects in an innovative and timely manner.

Millennium Research Laboratories
Millennium Research Laboratories (MRL), was founded in 2002 by a founding group that possess decades of combined experience in the fields of polymer science, advanced materials, drug discovery, and development.	MRL offers a wide spectrum of services and expertise in scientific, professional, technical, manufacturing, quality control, and regulatory fields.	MRL's understanding of the cost pressures in today’s pharmaceutical environment ensure that we develop products that can be manufactured in a timely and reproducible manner using cost effective materials.

NextGen Sciences
Biomarker discovery.	Rapid biomarker assay development.	Biomarker testing.
CSF 19-protein multiplex assay – test samples now!

NORMA
NORMA is a contract research organisation that conducts clinical trials in northern Europe.	NORMA conducts phase I–IV clinical trials for pharmaceutical and biotech companies.	NORMA has participated in over 300 clinical trials across a range of therapeutic areas.
NORMA is a flexible and co-operative business partner for clinical trials.	NORMA has a reputation as a trusted contract research organisation for clinical trials.

Norwich Clinical Research
Norwich Clinical Research Associates (NCRA) is a competitively priced, flexible contract research organization (CRO) with the industry, regulatory, and clinical expertise to see clinical development from all sides of the process.	Norwich Clinical Research Associates will provide rapid, accurate, cost-effective services to the pharmaceutical, medical device and nutraceutical industries, meeting the industries’ specific outsourcing needs for quality clinical research.	Specialising in Phase I-IV pharmaceutical and 510(k) through PMA clinical studies for product development, NCRA conducts in entirety small to large clinical trials from protocol design to completion of the final reports for regulatory submission.

NOTOX
An overview of Notox sites located in Hertognbosch, the Netherlands.	Cleaning the building sites, Hertogenbosch, the Netherlands, July 08.	Facts & figures: overview of vivarium, laboratory and office space.
Preclinical development.	Toxicology research services.

OnQ Research
OnQ Research is a full service South African contract research organisation that offers services to assist with the entire continuum of clinical research.	OnQ Research is a contract research organisation with experience in many areas of clinical research.	OnQ Research’s staff has international clinical trial project management experience.
South Africa is an excellent location for clinical trials as it offers varied patient populations and therapeutic areas.	OnQ Research facilitates the development of skilled clinical research sites in locations across Africa.

Patheon
Patheon is a leading global provider of contract development and manufacturing services to the pharmaceutical industry.	The 4·6·8 Promise™ ensures that Patheon will have your projects completed in the fastest possible timeframe, without compromising the high standards of work you demand.	Offering accelerated delivery of Phase I clinical trial materials.
Leading the way in accelerated pharmaceutical development and product transfer.	Please click to see an enlarged version of the matrix.

Pipeline Biotech
Research pharmacology provides proof of concept for drug efficacy.	Our experienced staff provides quality results of a high technical standard.	The health status of laboratory animals is monitored according to FELASA guidelines.
We are GLP and GMP compliant, and certified and audited by the National Medicines Agency in accordance to the OECD guidelines.

Pronexus Analytical
Sampling molecules by in vivo microdialysis.	Microdialysis is a major tool in functional pharmacology and evaluation of CNS drugs.	Functional/neurochemical evaluation of mouse phenotype: the effect of repeated forced swim test on noradrenlaine levels in the hippocampus of wild-type and galanin-overexpressing mice (PNAS, 2004).
Determination of DA, NA, 5-HT and their metabolites in the rat striatum by HPLC with electrochemical detection.

Quotient Bioresearch
GMP chemistry and isotope synthesis.	In vitro metabolism.	Bioanalysis and central lab.
Microbiology.

SBW
The Infodix staff has over 80 years of experience in discovery informatics, and consists of computer science, chemistry and pharmacology specialists, including research directors, bio and chemoinformaticians, application programmers and chemists.	Biodix is located within the NIPER campus in Chandigarh, India, which is a central national campus for pharmaceutical sciences; it's on a 130-acre site that has excellent transport connections by air, train or highway.	The Toxis facilities include 2,000m² GLP-compliant rodent laboratory facilities; access is restricted to Toxis and animal care personnel and the facilities are monitored by veterinary surgeons and GLP-certified technicians.
Customers will be provided with secure, authorised and monitored access to SBW Extranet services for progress reporting and data transfer; this service is accessible via an SSL-secured website.	In addition to providing services SBW acts as your strategic partner in drug research, providing you with comprehensive solutions to get the best out of your research efforts.

Solid Form Solutions
Solid Form Solutions' salt screening approach has been developed from many years' experience in the pharmaceutical industry.	Solid Form Solutions' polymorph screening protocol provides a clear understanding of the polymorphic space around an API and identifies the polymorphic form for further development.	Batch process optimisation provides an optimised process and low-risk route to manufacture.
Solid Form Solutions’ synthetic chemistry services can be used standalone or integrated with the screening services as part of a complete early chemical development programme.

Sovicell
TRANSIL® ready-to-use assay kits are smart dialysis systems that use an immobilised biological matrix with a very large surface area.	Sovicell's brain absorption kit is a ready-to-use assay kit that assesses how drug candidates pass across the blood-brain barrier.	The TRANSIL ready-to-use plasma protein binding kit is designed to assess the binding of drugs to plasma binding protein.
The TRANSIL ready-to-use intestinal absorption kit is designed for rapid assessment of drug candidates' ability to cross the intestinal epithelium.	The TRANSIL high-protein binding assay is based on the partitioning of the test item between the plasma and membrane.

Sygnature Chemical Services
Sygnature's pharmaceutical industry-experienced medicinal chemists have considerable drug discovery experience.	We contribute resources, chemistry expertise, intellectual input and drug discovery know-how to collaborations.	Sygnature occupies modern, state-of-the-art laboratories in BioCity, Nottingham.
We can apply virtual screening and high-throughput chemistry to generate molecules with desirable lead-like properties.	Sygnature works closely with the client's scientists to accelerate compounds into development and increase the value of their discovery projects.

Toxikon Europe
Toxikon Europe is a leading contract research organisation that provides high-quality preclinical safety studies to the life science community.	Toxikon has vast expertise in extractables and leachables (E&L) testing, and can assist in the assessment of scientific data obtained in E&L studies, via a toxicological risk assessment.	Toxikon Europe cooperates with leading container / closure manufacturers and pharmaceutical companies to help these industries comply with the new requirements of container / closure testing.
Besides extractables and leachables testing, Toxikon offers a wide range of preclinical testing capabilities for the pharmaceutical industry.	Biopharmaceuticals are becoming increasingly important as novel therapeutics for human disease; specialised testing using molecular biology and immunoassay techniques are available as well as animal models to evaluate immunogenicity and immunotoxicology.

Trenzyme
Trenzyme offers highly customised services, from recombinant expression to mammalian cell line development.	The modular cross organism expression technology platform allows the parallel expression of a given target, from E. coli to mammalian cell lines, exploiting the benefits of each host system.	Due to the ExoIN technology stable, homogeneous cell lines with tunable target expression can be generated within weeks instead of months.
cytobox™ offers easy online ordering of stable customised cell lines, from gene synthesis to stable CHO or HEK293-based cell lines, within 30 business days – timeline and target expression guaranteed.

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