IPS Therapeutique: White Papers

Predicting TCA Toxicity Using In Vivo and Ex Vivo Juvenile Safety Models
Wednesday, May 11, 2011 by IPS Therapeutique The tri-cyclic antidepressant (TCA) amitriptyline is used in the treatment of nocturnal enuresis at doses of 2-7mg/kg in children, despite existing reports of severe cardiac toxicity at doses...