Collagen Induced-Arthritis Test
22 May 2007
Neurofit is now pleased to offer the collagen induced-arthritis test in rats to its customers. This test evaluates the potency of compounds to inhibit arthritis inflammation.
Briefly, arthritis is induced in female Lewis rats using Bovine type II collagen. At the time of sensitization, each rat receive a first subcutaneous in the tail. Seven days later, a second collagen injection is carried out (boost injection).
Arthritis is monitored at day seven, 14, 17 and 21 post-immunization using the hind paw swelling as parameter. In this model, a daily dexamethasone treatment from day 14 to 20 fully prevents the hind paw swelling.
If you need further information concerning this assay, please do not hesitate to contact us.
Neurofit also offers a wide range of validated in vitro and in vivo screening tests for psychiatry, neurology and ophthalmology. For a complete listing of Neurofit offer, please refer to our website. We publish a scientific newsletter with focus on screening tests for a specific disease every second month. To subscribe, please register on our website.
