Quotient Bioresearch - Drug Development from Discovery to Late Phase Clinical Trials

Quotient Bioresearch is a drug development partner research employing over 300 people. We have three laboratory facilities in the UK, each with specific facilities and experience but tied together by a shared passion for science, customer service and above all excellence.

Bioanalytical expertise, radiosynthesis capabilities and microbiology services

With its established reputation in providing high quality analytical services, Quotient Bioresearch is your drug development partner of choice.

Our unique heritage and appoach makes Quotient Bioresearch the only drug development partner that provides:

• Fully integrated discovery and regulatory DMPK including GMP radiosynthesis
• Expertise in the bioanalysis of small molecule and biological drugs and biomakers from the world's leading sports drug surveillance laboratory
• Europe's most comprehensive microbiology laboratory for the development and support of antimicrobials

Quotient Bioresearch provides tailored services to our client requirements and high quality standards. Our key service area includes:

GMP chemistry and isotope synthesis

• Radiosynthesis (14C, 3H, 35S, 125I)
• Stable isotope labelling
• Repurification and storage
• GMP qualified release lab
• GMP synthesis of APIs and IMPs

Discovery support

• High throughput in vitro discovery assays
• Rapid in vivo pharmacokinetics studies (cassette and single dose)
• Rapid turnaround non-regulatory bioanalysis

In vitro metabolism

• Defining exnzymology of drug metabolism
• Identifying drug interaction risks
• Elucidating idiosyncratic risks and transporter issues

Integrated ADME programmes

• Kinetics for drug and total radioactivity
• Mass balance studies
• QWBA
• Metabolite profiling and identification

Bioanalysis and central lab

• Broad-based analytical capabilities for small molecules and biologicals
• Bioanalysis of drugs and biomarkers for pharmacokinetics and pharmacodynamics
• Clinical chemistry
• Sample kits and global logistics

Microbiology

• Efficacy of new agents against microbes including atypical bacteria and fungi
• Evaluation of potential resistance development in target organisms
• Full scale global surveillance studies, including molecular analysis or resistance and epidemiology
• Microbiology reference laboratory for clinical trails

Other industry services

Quotient Bioresearch works with clients ranging from pharmaceutical and biotech to consumer product chemicals and agrochemical companies. We pride ourselves on our ability to offer cost effective solutions for current regulatory or product development challenges including project management and data handling.

Agrochemical and chemical solutions

Either utilising in-house capabilities or by accessing a strategic network of specialist partners, Quotient Bioresearch is able to provide a comprehensive range of services for international product registration of agrochemicals, biocides and industrial chemicals.

Project management solutions

Our well established management infrastructure combined with a passion for science and service means we can help you put together bespoke studies built completely around your needs.

Our project managers and study directors become a single point of contact for your study, updating you regularly on progress and helping design the most effective and accurate studies to achieve your aims.

From analysis to reporting, logistical support to candidate selection, there are very few parts of non-regulated and regulated programmes we can’t help with. Contact us to discuss your specific needs or read more about how we can help.