Solid Form Solutions Salt, Polymorph and Co-Crystallisation Screening, Crystallisation Development, and Synthetic Chemistry
Solid Form Solutions is a world-leading contract research organisation (CRO) providing the pharmaceutical industry with chemical development services. Our work programmes include:
- Salt screening
- Co-crystal screening
- Crystallisation screening
- Polymorph screening
- Batch process development (scale-up)
- Custom synthesis
- Physical properties and developability testing
Our services can either be used separately to solve specific problems, or in parallel to deliver a larger drug development programme that will seamlessly bring the best synthetic chemistry route to the most developable solid form of a drug molecule.
Our aim is to be flexible, understand our clients’ requirements and deliver workable solutions. Whether our expertise is required to locate a synthetic route or tackle specific problems encountered during drug manufacture, Solid Form Solutions will provide an unrivalled service.
Salt screening and selection
Solid Form Solutions provides a salt screening and selection programme that aims to deliver a number of developable salt forms. Our services are focused on screening a range of counterions based on:
- The pKa of the API
- The market precedence of each counterion
- The available toxicology data of each counterion
- Past salt-screening experience
- Formulation plans
Solid Form Solutions provides polymorph screening services that focus on delivering the most developable crystalline form, coupled with a thorough understanding of the polymorphic space surrounding an API. Furthermore, our extensive polymorph screening programme and thorough examination of data ensures better protection of our customers’ intellectual property (IP).
Our unique approach to polymorphism allows us to carry out a very large number of experiments on a very small amount of drug material.
Our study read-out time can be very short (two weeks) without any compromise on data quality, or process space investigated.
The scope of our polymorph screening programme and salt selection studies can be tailored to meet the requirements of our customers.
Solid Form Solutions’ approach to co-crystals is based on over ten years’ experience in the co-crystal sector, coupled with detailed in-house research. The design of our screens incorporates a wide range of methods that include, among others:
- Modelling techniques
- Solvent drop grinding
- Slurrying experiments
As well as aiming to modify the physicochemical, co-crystal screening at Solid Form Solutions is extensive enough to provide our customers with the further IP protection of their APIs.
Often when an API enters into development the solid form is not crystalline. Solid Form Solutions offers an extensive crystallisation service focusing on obtaining a crystalline and easily isolated form of the drug.
Combined with our knowledge of downstream processing Solid Form Solutions will deliver a scalable solution.
Batch process optimisation
Solid Form Solutions’ batch process development service is aimed at developing a bench-scale process into a robust procedure that can easily be transferred to a plant. Solid Form Solutions aims to deliver a controlled process that yields batches of API that exhibit consistent physical properties.
Custom synthesis of novel compounds and intermediates
Our experienced synthetic chemistry team is capable of locating the first route to a drug molecule and delivering a scaled-up, optimised process. Our capabilities include:
- Laboratory synthesis of novel compounds and intermediates
- Expansion of molecular libraries
- Hit to lead optimisation
- Lead compound scale-up for advanced studies
- Extensive analytical support and services
- Synthesis from the milligram scale to pilot plant
Our specialised equipment capability includes:
- Impurity isolation and identification
- Autoclaves for hydrogenation and pressure reaction
- Fractional distillation
- Pilot plant reactors (including continuous flow)
- High-field NMR ¹H, ¹³C, N and ³¹P nuclei (including 2D NMR for full structure elucidation)
- Mass spectrometry (EI, CI, ESI and MALDI)
Whether our synthetic work programmes are used separately, or in tandem with a screening activity, Solid Forms Solutions will deliver the most efficient synthetic chemistry.
Quality control of salt, polymorph and co-crystallisation screening, crystallisation development, and synthetic chemistry
Solid Form Solutions works to the highest possible quality standards, and has a dedicated team to ensure these standards are met. As a part of the studies performed at Solid Form Solutions, clients can have their projects audited by the Solid Form Solutions QA section. Independent of the technical team, the QA section will report regularly to clients on the quality aspects of their project, and provide final sign off.
Products and Services
At just over two years old, Solid Form Solutions has grown quickly, continually building more business, hiring more staff, and adding more services. The unique array of high-quality services the company provides, along with its rapid growth, have led to Solid Form Solutions being awarded the NexxRead more
Solid Form Solutions, a world-leading contract research organisation (CRO) for the pharmaceutical industry, is pleased to announce its attendance at this year's AAPS in New Orleans on 15-17 November 2010. Come and meet the team at booth#602. Our experts will be on hand to answer your quRead more
Come and meet our experts at this year's worldwide CPHI. Either pop along to our stand or contact firstname.lastname@example.org to schedule your meeting. Come along and sample our traditional whisky tasting on 6 October from 3pm at stand 6E103. We look forward to seeing you there.Read more
Solid Form Solutions (SFS) today announced that four new staff members have joined the company to support a number of large contracts. The Roslin-based CRO specialises in providing the pharmaceutical industry with solid form screening and analytical services, including salt, polymorph, co-crystalRead more
Are you attending Chemspec? Come meet with us at this year's Chemspec Europe, to be held on 9-10 June 2010 at Messe Berlin, Germany. We will be exhibiting at stand number U6. Contact us now to schedule your meeting or pop along and see us; we look forward to meeting you.Read more
After inspection by the British Standards Institute, Solid Form Solutions (SFS) has now been certified to ISO9001:2008. The audit's success stemmed from hard work and overall team effort from all the staff who have fully embraced the quality culture, as demonstrated by the auditors finRead more
Solid Form Solutions is pleased to unveil its custom synthesis service to complement its solid form screening programmes. Using a 'quality by design' approach, the integration of the two services provides a powerful and rapid low-risk route to manufacture. Our experienced synthetic cheRead more