Vivotecnia - Animal Models for Studying the Efficacy of Drugs

Vivotecnia was founded with the aim of setting standards in contract research in toxicology, pharmacology and biomedical sciences. We count numerous multinational pharmaceutical, chemical, food and biotechnological companies among our customers, as well as many national and European research centres.

The introduction of process optimisation techniques, flexible personnel organisation, close contact with sponsors, dynamic reporting and state-of-the-art information technologies allow us to provide the highest quality services at competitive prices in record times.

CONDUCTING ANIMAL STUDIES IN A HUMANE WAY

Vivotecnia prides itself on conducting quality in-vivo studies while giving the highest importance to animal welfare, working ahead of regulations to conduct animal studies in a humane way. Our services are supported by a highly qualified and motivated professional team of veterinarians, chemists, pharmacists and biologists with extensive experience in many different research areas. Many members of our team have previously worked for the industries we now service, giving a deep understanding of your needs.

Our animal facilities are designed to accommodate different animal species commonly used in experimental models - from pigs and dogs to different species of rodents. These facilities boast of rooms with all the necessary equipment to perform numerous pharmacological, biomedical and toxicological assays. These services include efficacy, toxicology, pharmokinetics, drug discovery and genotoxicity.

EFFICACY

• CNS and behaviour
• Infection models (complying with the safety regulations for type II biological trials)
• Xenograft and carcinogenesis models

TOXICOLOGICAL STUDIES IN ANIMAL MODELS

Vivotecnia offers a wide range of toxicological studies in animal models. These are performed according to guidelines issued from international institutions and regulatory agencies (EMEA, FDA, OECD, etc.).

The studies are designed and performed according to particular needs of our clients. Experimental protocols are carried out under Good Laboratory Practices (GLP) in accordance with international guidelines. This allows us to perform preclinical toxicological studies with the regulatory quality to succeed in marketing authorisation.

• Acute toxicity
• Subacute toxicity
• Subchronic toxicity
• Chronic toxicity
• Genotoxicity
• Carcinogenesis
• Reproductive toxicity
• Skin sensitization

PHARMACOKINETICS

Pharmacokinetic studies allow the understanding of the biotransformations that a substance undergoes when incorporated by the body during the Absorption, Distribution, Metabolism and Excretion (ADME) process. The study of these processes is carried out by determining levels of the test substance and its metabolites in plasma and other biological samples or tissues and relating them to classical pharmacokinetic models.

We perform complete pharmacokinetic studies under GLP standards, as well as preliminary assays coupled to drug discovery that will support the planning of a complete study. The set-up and validation of bioanalytical method procedures are performed in collaboration with experienced partners working as well in compliance with GLPs.

DRUG DISCOVERY

Vivotechnia's range of drug discovery services includes:

• Breeding and management of transgenic mice colonies
• Embryo transfer and criopreservations
• Cell line culture and delivery
• In-vitro screening

GENOTOXICITY

Vivotecnia offers a pack of studies for regulatory level testing of genotoxicity. This includes:

• Ames test - bacterial reverse mutation
• Micronucleus test - mammalian erythrocyte micronucleus test
• Mouse lymphoma assay - In-vitro mammalian cell gene mutation test

Vivotecnia has been certified by the health authorities to work under Good Laboratory Practices (GLP): B.P.L I/05.04/018-CM. Our company was the first Contract Research Company in Madrid to comply with GLP standards.

COMPLYING WITH REGULATORY REQUIREMENTS

Vivotecnia is committed to advising our customers in the design and planning of their research projects, helping them comply with regulatory requirements. We are aware that most of our reports are aimed at regulatory purposes so our reporting system is designed to allow the final reader to swiftly find all the relevant findings and easily understand conclusions.