Malvern Instruments Biopharmaceutical and Drug Development
Malvern offers characterisation tools for molecular analysis and small drug discovery to help accelerate development for the pharmaceutical industry.
Systems for critical material attribute information
Malvern has a wide range of experience in small molecule pharmaceuticals.
Services include systems that provide information on variables identified as critical material attributes (CMA) such as particle size, shape and chemical identity, or molecular weight and size.
Whether characterising particle size and morphological properties of a novel active pharmaceutical ingredient (API) or rheological attributes of a new chemical entity (NCE), Malvern can achieve efficiency using common platform technologies.
Small molecule drug discovery and development
Malvern’s range of analytical solutions focuses on testing and manufacturing requirements, while taking into account time and cost pressures, as well as sample availability and complexity.
Label-free technologies appeal to researchers across various applications, including biological research, biotherapeutic and small molecule drug discovery and development, immunogenicity studies, vaccine development and quality control.
Label-free techniques are used in the direct study of native molecules, and generate biologically relevant data enabling understanding of molecular interactions without using artificial probes or labels.
Isothermal titration calorimetry for biomolecular interactions
Malvern’s MicroCal range includes isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC).
ITC is used in quantitative studies of a range of biomolecular interactions, that work by directly measuring heat that is either released or absorbed during a biomolecular binding event.
By providing a complete thermodynamic profile of the molecular interaction, ITC can explain mechanisms’ underlying interactions, and enable more confident decision-making in hit selection and lead optimisation.
DSC is used to characterise stability of a protein or other biomolecules directly in its native form, and achieves this by measuring heat change associated with the molecule’s thermal denaturation.
Precise and high-quality data obtained from DSC provides vital information on protein stability in process development, and in the formulation of potential therapeutic candidates.
Size exclusion chromatography systems for assessment of product purity
Malvern’s analytical toolbox for biopharmaceutical development is tailored to provide trusted solutions such as OMNISEC size exclusion chromatography systems to assess product purity.
The Zetasizer range is also available for sizing and zeta potential analysis for product stability.
The company’s Archimedes and NanoSight systems quantify early aggregation in bioformulations.
Malvern’s technical experts are available to support and work with researchers to find the right solution for individual challenges.
Providing agile technology development in partnership with its Bioscience Development Initiative, Malvern is always looking for new solutions to enable quicker, easier and more useful analysis.
The company has a suite of instruments that provides access to biophysical information focused on accelerating through characterisation studies, formulation development and quality control.
Malvern provides high-quality products and helps clients to achieve maximum return from investment.
Products and Services
Malvern Viscosizer TD with Taylor Dispersion Analysis
Malvern Viscosizer TD uses Taylor dispersion analysis for automated biophysical characterization.
MicroCal PEAQ-DSC Automated
MicroCal PEAQ-DSC Automated is a high-quality protein stability analysis instrument, designed for the regulated environment. This system delivers high-throughput, sensitive protein stability analysis, with low-sample consumption, in an automated, integrated platform for increased productivity.
MicroCal DSC Range
The MicroCal DSC range contains two high-quality MicroCal PEAQ-DSC microcalorimeters designed for analysis for the regulated environment. These powerful devices enable the characterisation of thermal stability for proteins and other biomolecules, primarily for biopharmaceutical development and manufacture.
MicroCal PEAQ-DSC Manual
The MicroCal PEAQ-DSC system offers sensitive, simple microcalorimetry for time and cost-effective stability testing and comparability analysis.
Viscotek UV Detector
Viscotek UV detector provides accurate measurements of the polymer or protein concentration profile that is essential to good molecular weight or structure data.
Zetasizer AT for DLS
Dynamic Light Scattering – Common Terms Defined
There are a number of sources of information that give a mathematical description of the terms used in light scattering. However, these will not usually give assistance in understanding their practical application.
Gold Nanoparticle Applications and Characterisation by Nanoparticle Tracking Analysis
Gold nanoparticles are one of the most popular and extensively researched type of nanoparticle.
An Analysis of Polymer Branching Using GPC / SEC Methodology
Polymer branching has been proven to have a potentially considerable impact on many physical properties of synthesised polymers, such as the disruption of crystallinity and a possible increase in single chain density and chain entanglements.
Reasons to Replace Your Viscometer with a Rheometer
It may be time to assess what a modern rheometer can do, especially in comparison to a viscometer.
An Analysis of Antibodies Using Multi-Detector SEC Methodology
Antibodies' innate ability to direct their neutralisation attacks toward specific components in harmful agents has generated a large amount of interest within the pharmaceutical industry.
Stability Analysis of Proteins for the Biopharmaceutical Industry
The biggest class of biopharmaceuticals on the market is monoclonal antibodies (mAb) and their specific binding nature provides an opportunity to use them to modulate pharmaceutically-relevant molecule activity to control or prevent disease.
Supplier of analytical X-ray instrumentation and software PANalytical has announced the introduction of a new Epsilon 1 X-ray fluorescence (XRF) spectrometer.Read more
Understanding the make-up of crystalline structures is a vital aspect of the characterisation of new compounds, and can be regarded as an important first step towards the possibility of tailoring its properties.Read more
Malvern to Host Webinar on Using Multi-Setection size-exclusion chromatography to Evaluate Biosimilarity
Malvern has announced it will be hosting a new webinar presenting size-exclusion chromatography (SEC) data and discussing the impact of different formulations and external stress conditions on Monoclonal antibodies and biosimilar molecules.Read more
Malvern has announced it will host a new webinar discussing the difference between rheometers and viscometer to help viewers decide which of the two is most suitable for their application.Read more
Malvern to Host Webinar on Characterisation and Optimisation of Particle Size and Shape of Metal Powders
Efficiency of the production process of powder bed additives is reliant on packing density and flow behaviour of metal powders involved.Read more
Malvern has announced it will be unveiling its new protein stability characterisation product for regulated environments MicroCal PEAQ-DSC in an upcoming webinar.Read more
Malvern has announced it will present a webinar discussing the particle tracking analysis (PTA) method (ISO19430) and what it means for nanoparticle measurements.Read more
Malvern has announced it will be presenting a webinar discussing the use of laser diffraction as a technique in characterising nebulisers and how it is helpful in understanding the delivery of the drug product.Read more
Size exclusion chromatography (SEC) is a popular analytical technique for studying protein molecular weight, oligomeric state, aggregation, and conjugation.Read more
Malvern has announced it will host a live-panel webinar for the discussion of challenges submitted in an online form on the company's website.Read more
Malvern Hosts Webinar on Optimising Gel Permeation Chromotography (GPC) Measurements by Combining High-Performance Columns and Powerful Advanced Detectors
Malvern has announced it will be hosting a webinar discussing gel permeation chromatography (GPC).Read more
Malvern has announced its latest webinar discussing the types of technologies used for analysing particulates in injectable drugs.Read more
Advancements in portable electronic devices such as mobile phones and laptops has increased demand for advances in battery technology.Read more
Malvern Hosts Webinar on Using a Diffusion Interaction Parameter Measurement for Taylor Dispersion Analysis
Malvern has announced it will host a webinar discussing the use of a diffusion interaction parameter (kD) measurement for the Taylor dispersion analysis in early stages of development.Read more
Malvern will be hosting a webinar to discuss the rheological requirements of paintings and coatings, as well as how they can be measured using a rotational rheometer.Read more
Malvern has announced it will be demonstrating the NanoSight NS3000, which uses Nanoparticle Tracking Analysis (NTA) to measure nanoparticles and concentrates.Read more
Cosmetics, paints, inks, paper, drug delivery, personal care, food or intra-lipid emulsions are made up of multi component chemistries. Most products go through a stage where different phases co-exist such as emulsions, suspensions or dispersions and as such require a specific amount of stability in order to meet expected performance criteria.Read more
Key data for the approval of a nasal spray containing mometasone furoate has been obtained by the Food and Drug Administration (FDA) through the use of Malvern's Morphologi G3-ID system.Read more
Malvern Instruments has launched the new Zetasizer AT, a robust, online, automated analyzer that uses dynamic light scattering (DLS) to automatically measure the size of nanoparticles in suspensions and emulsions.Read more
Malvern will be hosting a webinar on 8 March at 10:30AM EDT.Read more
NanoChOp Project Highlights Value of NanoSight for Monitoring Nanoparticle Characteristics in Biological Systems
Researchers working on the European Metrology Research Project NanoChOp (Chemical and Optical Characterisation of Nanomaterials in Biological Systems), funded by EURAMET, have concluded the NanoSight Nanoparticle Tracking Analysis system offers a unique insight into the behaviour of nanoparticles in biological systems.Read more
The latest software release and expansion of the global technical specialist team highlight Malvern Instruments' ongoing commitment to extending and supporting the application of NanoSight, a nanoparticle characterisation technology with unique capabilities.Read more
A collaboration between Malvern Instruments and Bio-Rad from Hercules, California has delivered new analytical tools for the rapid identification of unknown particles.Read more
Insights shared by Particle Characterization Laboratories director William Bernt highlights the impact of adding a Malvern NanoSight nanoparticle tracking analysis (NTA) system to the toolkit for nanoparticles.Read more
New tools from Malvern that address specific analytical challenges in biopharma development will be at the AAPS Annual Meeting and Exposition 2015, in Orlando, US.Read more
Insight from CP Kelco, a global leader in the specialty hydrocolloids market, provides a blueprint for the intelligent, cost-efficient deployment of gel permeation/size exclusion chromatography (GPC/SEC) in biopolymer manufacture.Read more
Malvern has established a new biopharmaceutical applications laboratory in the heart of San Diego's biotechnology cluster.Read more
Malvern Instruments has launched an improved rSolution platform on their Kinexus rotational rheometer.Read more
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