ALSACHIM - Custom Stable Isotope Labelled Compounds Synthesis, PET Precursors and Medicinal Chemistry Services

ALSACHIM is an independent contract research and development organisation that specialises in stable isotope-labelled compounds, metabolites and pharmaceutical related substances, and rare chemicals for medicinal chemistry research and analytical purposes.

We supply our products to customers all over the world, spread throughout the chemical discipline including the pharmaceutical and biotech industry, clinical and bio-analytical CROs and related research institutions.

ALSACHIM’s team of highly experienced scientists can effectively support your research with services that include custom synthesis and chemical development complemented by integrated state-of-the-art analytical services (NMR, MS, HPLC-MS).

CUSTOM STABLE ISOTOPE LABELLING

Pharmacokinetic studies have traditionally used radio-labelled compounds as a means of evaluating body Absorption, Distribution, Metabolism and Excretion (ADME). New analysis technologies now make it possible to use compounds enriched with stable isotopes such as carbon-13 and deuterium as alternatives to radioisotopes.

If you are interested in stable isotopes, only a limited number and variety of isotopically enriched intermediates are readily available. The intermediates used in the synthesis route for your desired target compound may not exist as labelled compounds; thus, a whole new synthesis will be needed for incorporation of the isotope of interest.

CUSTOM SYNTHESIS OF STABLE ISOTOPICALLY LABELLED MOLECULES

ALSACHIM is your complete source for isotopically labelled compounds of high purity and high isotopic enrichment, with specific labelling patterns in complex molecules and drugs for metabolism and biochemical studies.

ALSACHIM offers custom synthesis of stable isotopically labelled molecules including:

• Pharmaceutical Intermediates
• Peptides
• Biologically active molecules
• Controlled drug standards (DEA)
• NMR reference standards
• Metabolites
• Isotopically-labelled reference standards

RARE PHARMACEUTICAL BUILDINGS BLOCKS

ALSACHIM specialises in multi-step custom synthesis of compounds that are not commercially available. We synthesize novel and rare drug-like molecules in the scale ranging from milligram to 100g quantities every day.

Rare buildings blocks are available from ALSACHIM’s catalogue and will provide our customers with original NCEs for their drug discovery programs.

FOCUSED LIBRARY SYNTHESIS

ALSACHIM has expertise in the design and synthesis of small molecules, heterocyclic-based peptidomimetics and drug-like libraries, using both solution and solid-phase synthesis approaches. Our efforts are focused on working with customers to generate moderate-sized focused libraries.

PET PRECURSORS

The world's need for PET tracers is growing steadily. The key to growth and greater utilization of molecular imaging is the development of new and more specific biomarkers. At ALSACHIM, we also provide PET precursors and PET standard for your research studies.

ANALYTICAL LAB EQUIPMENT AND SYNTHETIC FACILITIES

ALSACHIM has excellent laboratory facilities at its disposal, including modern analytical equipment (high-field NMR 400MHz, MS), chromatography systems (HPLC, preparative and analytical LCMS), combinatorial chemistry facilities, 1L, 2L, and 4L reactors, and microwave systems.

SYNTHESIZED COMPOUND CATALOG

The catalog reports the compounds we have synthesized for different customers. For your information, since September 2006, we offer to our customers the desired labeled molecule with a minimum of four isotopes.

Indeed, we prefer to offer to our customers 13C labeled drugs rather than 2H drugs to ensure the stability of the labeling and to allow NMR studies as CP-MAS studies. In addition the price remains the same with ALSACHIM.

Moreover we may perform custom syntheses of your desired drugs. The timeline is usually four weeks. Please feel free to contact us for further information.