Bachem GMP Custom Peptide Synthesis and Custom Peptide Manufacturing

Technology-based peptide chemistry solutions

Bachem provides technology-based peptide chemistry solutions. The company offers a comprehensive range of services throughout the pharma and biotech industries.

It is a specialists developer of innovative, efficient manufacturing processes, as well as dependable production of peptide-based active pharmaceutical ingredients. Its services portfolio is completed by a complete range of biochemicals and exclusive custom syntheses for research labs.

The group has its headquarters in Switzerland, with subsidiaries in Europe and the US giving it a truly global reach. Customers can be assured of quality and innovation.

Bachem. Pioneering Partner for Peptides

Custom peptide synthesis

In the business segment research chemicals (which accounts for 20% of Bachem’s sales revenue) Bachem offers peptide custom synthesis and products that are marketed through the Bachem catalogs, containing more than 9000 products available from stock.

Bachem’s range of products is focused on peptide building blocks, natural and unnatural speciality amino acids, peptide fragments, an impressive list of neuropeptides, peptide inhibitors, peptide substrates, and complex organic molecules, as well as resins and linkers for peptide synthesis.

Custom peptide manufacturing

Bachem has the required capacity for custom peptide manufacturing of new active ingredients for the biotech and pharmaceutical industry that are either in clinical development or have already been approved for commercial use.

These new chemical entities (NCEs) must be produced and analyzed in accordance with the rules of GMP. Bachem offers its peptide custom manufacturing and the related services from the early preclinical phase onwards. Bachem offers them at such an early stage so that an optimal basis can be created for a reliable partnership with the customer right up to market approval and beyond. This business segment accounts for 50% of Bachem’s sales revenue.

Generic active pharmaceutical ingredients

Bachem supplies peptides and organic active ingredients whose patent protection has lapsed. This business segment accounts for 30% of Bachem’s sales revenue.

Further opportunities for growth with peptide and complex organic active ingredients lie with new innovative forms of delivery, such as sustained release depots. Bachem’s customers can apply for patent protection for these depots, giving them a potential similar to that of new chemical entities.

In this field, Bachem offers:

  • Leuprolide, Goserelin, Gonadorelin, Triptorelin, Histrelin, Fertirelin, Nafarelin, Antide, Buserelin, Deslorelin
  • Calcitonin, Elcatonin, GRF, CRF, Thymopentin, Thymosin
  • Aviptadil, Glucagon, GLP-1 (7-37), Ghrelin, Peptide YY, Peptide YY (3-36), Somatostatin, Octreotide, Sincalide, Secretin
  • Desmopressin, pTH (1-34), Protirelin, Angiotensin, Splenopentin, Endothelin, IGF-1, Dynorphin A, Terlipressin, Tetracosactide, -Melanotropin
  • Carbidopa, Etomidate, Zonisamide, Propofol, Xylazine, Antazoline, Acetylcysteine, Carbocysteine, Pergolide, Trandolapril, Trimetazidine, Xipamide

Finished dosage form

For its peptides, Bachem does not offer the API only, but also the finished dosage form (FDF). Through Bachem’s fully owned subsidiary in Germany, clinical trial materials in vials, ampoules and pre-filled syringes – released by Bachem’s Qualified Person (QP) – are available (Clinalfa® brand).

This service supports our customers’ needs and shortens time-to-market: from research grade chemicals and peptide custom synthesis, to custom synthesis of complex organic molecules, GMP peptide manufacturing of NCEs, and generic peptides and peptides in their finished dosage form.

Custom manufacturing of cytostatic and cytotoxic compounds

Bachem has extended its product offering with custom manufacturing of cytostatic and cytotoxic peptides and complex organic molecules. These substances are used as active ingredients for cancer therapy and have to be manufactured according to the strictest safety requirements for both staff and the environment.

Full regulatory support

Bachem has the experience and the financial resources to meet growing regulatory and GMP demands. We have also submitted dozens of technical packages in support of successful IMPD and IND applications.

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Press Release

Bachem Adds 11 New Research Products to Online Catalogue

Bachem is continuously expanding and updating its extensive range of biologically active peptides, amino acid derivatives, biochemicals and immunology products.

White Papers

Melusine Venom Libraries: Designed to Discover Tomorrow’s Drugs

Melusine Venom Libraries are high-quality venoms prepared and pre-fractionated on an automated platform and dispensed in micro-plates ready for high throughput screening (HTS) in targeted lead discovery projects.

Address
Bachem AG

Hauptstrasse 144

CH-4416 Bubendorf

Other

Switzerland

+41 61 935 2333 +41 61 935 2325 Online Catalogue www.bachem.com

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Press Release

17 May 2013

Bachem is continuously expanding and updating its extensive range of biologically active peptides, amino acid derivatives, biochemicals and immunology products.

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9 April 2013

Bachem and Axon Neuroscience SE today announced that the two companies have entered into a collaboration under which Bachem manufactures Axon's investigational API and supplies it as a finished dosage form under Bachem's Clinalfa brand.

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14 March 2013

Bachem is continuously expanding and updating its extensive range of biologically active peptides, amino acid derivatives, biochemicals and immunology products.

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21 January 2013

Bachem is continuously expanding and updating its extensive range of products for your research purposes.

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5 November 2012

The Japanese Ministry of Health, Labour and Welfare (MHLW) has granted Bachem AG a renewed manufacturing licence in conformity with their regulations.

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17 September 2012

Bachem is continuously expanding and updating its extensive range of products for your research purposes.

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24 August 2012

Bachem Group reported sales of 76.2m CHF for the first half of 2012.

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19 October 2011

To enable quantitative studies of enzyme kinetics, enzyme substrates have been manufactured bearing chromogenic or fluorogenic moieties to allow for visualization using ultraviolet absorption and/or fluorescence spectroscopy.

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17 March 2011

Bachem is continuously expanding and updating its extensive range of products for your research purposes. We are pleased to present our latest product additions, which include several Pro-VGF-derived peptides, osteoblast activating peptides, and two deuterium-labelled API analogs. A number of pro

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12 January 2011

Bachem is continuously expanding and updating its extensive range of products for your research purposes. We are pleased to present our latest product additions, which include H-Pro-Gly-Pro-OH (PGP), a physiological substrate for the aminopeptidase activity of leukotriene A4 hydrolase and immunol

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16 November 2010

Bachem is continuously expanding and updating its extensive range of products for your research purposes. We are pleased to present our latest product additions, which include human C5a Anaphylatoxin, the deuterium-labelled octreotide analog ([ring-D5]Phe³) - Octreot

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13 September 2010

Bachem has announced that the company has concluded an agreement with Atheris Laboratories to market their Melusine® libraries, consisting of natural products isolated from animal venoms. The agreement includes services to assist customers with the identification of the active ingredients a

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1 September 2010

Solid-phase synthesis, especially the more convenient Fmoc variant, has become the routine method for assembling peptides. Standard resins such as Wang resin yield the 'free peptide', whereas resins such as SASRIN™ or 2-chlorotrityl resin have been developed for the option to keep protection

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22 August 2010

In the first half of 2010, sales of the Bachem Group fell to CHF73.9m as a result of the difficult market conditions. Trends in the most important business areas Generics in particular showed a sales decline of 27.4% in local currencies (LC) as a result of various

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18 July 2010

Bachem is continuously expanding and updating its extensive range of products for your research purposes. We are pleased to present our latest product additions, which include atrial natriuretic factor (1-28) (human), the NPY Y4 receptor-selective agonist DL-2,7-Diaminosuberoyl-((TyrRead more

23 June 2010

Thymosin β4 is a 43 amino acid peptide. It is the most abundant member of the β-thymosin family in mammalian tissue and is regarded as the main intracellular G-actin sequestering peptide. Thymosin β4 has multiple biological activities including prevention of apoptosis, reduction of

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21 June 2010

Bachem has announced that the company, on 16 June 2010, sold its complete stake in Polyphor to Ingro Finanz, which hereby increased its stake in Polyphor to 29%. The involved parties have agreed not to disclose the purchase price of the transaction. For more than ten years Bachem

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2 June 2010

Bachem and ISA Pharmaceuticals have announced the conclusion of an agreement for the manufacture of the active ingredients and the supply of finished dosage forms of ISA Pharmaceutical's immunotherapeutic HPV-SLP® product. The company has successfully concluded a clinical phase II

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21 April 2010

The complex formation between biotin and avidin or streptavidin is one of the strongest and most specific non-covalent interactions of a low-molecular weight compound with a protein. In practical use, the non-glycosylated streptavidin is preferred over the glycoprotein avidin as it shows less uns

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23 March 2010

Bachem is continuously expanding and updating its extensive range of products for your research purposes. We are pleased to present our latest product additions, which include the PAC1 receptor antagonist M65, the opioid peptide Gliadorphin-7, additional pseudoprolines, and several high-sensitivi

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18 March 2010

In 2009, despite difficult market conditions, the Bachem Group achieved sales of CHF181.8 million. Compared with the previous year, this corresponds to a sales decline of only 5.6% in local currencies. The mid-year deficit compared with the previous year’s period was therefore substantially

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10 February 2010

Bachem, the number one in the production of peptides at any scale, is and will remain your ideal partner for custom synthesis. Our proficient peptide synthesis techniques coupled with high capacity and efficient production equipment result in swift delivery and superior quality. Our de

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13 January 2010

Bachem is continuously expanding and updating its extensive range of products for your research purposes. We are pleased to present our latest product additions, which include Liraglutide, a GLP-1 analog, the rat alarin sequence, a range of ACTH peptides, and a high sensitivity EIA kit for the de

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18 November 2009

Bachem is continuously expanding and updating its extensive range of products for your research purposes. We are pleased to present our latest product additions, which include the novel biomarker copeptin, 6-Azido-hexanoic acid for 'click chemistry' and several other building blocks, the non-ioni

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18 October 2009

The coupling reaction is the critical step in peptide synthesis. In particular, the solid-phase approach relies on rapid peptide bond formation and complete conversion with a minimum of concomitant side-reactions such as racemization. To meet these requirements a plethora of coupling (

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18 October 2009

mondoBIOTECH and Bachem have announced the conclusion of a longterm cooperation. In the frame of the agreement with Interferon Medical Use in Collina d'Oro, Switzerland - a 100% affiliate of mondoBIOTECH Holding - Bachem provides its comprehensive know-how on peptides and its longstanding exp

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22 September 2009

Bachem is continuously expanding and updating its extensive range of products for your research purposes. We are pleased to present our latest product additions, which include a number of bioactive molecules, synthetic RANTES peptides, several LHRH impurities and a range of new immunology product

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20 August 2009

Several families of endogenous opioid peptides, the endorphins, enkephalins and dynorphins, have been identified in the mammalian central nervous system. The peptides of these families contain an N-terminal Tyr-Gly-Gly-Phe- sequence but are derived from different precursor proteins: proopiomelano

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15 July 2009

Bachem is continuously expanding and updating its extensive range of products for your research purposes. We are pleased to present our latest product additions, which include several Aβ mutants, the FPRL2 ligand F2L, Phylloseptin-L2, a novel antidiabetogenic peptide and a range of new immun

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10 June 2009

The 36-peptide apelin-36, which was originally detected in bovine stomach extracts, turned out to be the specific endogenous ligand of the orphan G protein-coupled receptor APJ. APJ has been shown to be a coreceptor for the infection of CD4-positive cells with HIV in the CNS, which can be blocked

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25 May 2009

Bachem has announced that Stephan Schindler, currently the head of Finance & Control Switzerland at DSM Nutritional Products, Kaiseraugst, will succeed Michael Hüsler as CFO of the Bachem Group in summer, later this year. Dr Rolf Nyfeler, CEO of Bachem, commented, "Michael H

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13 May 2009

Bachem is continuously expanding and updating its extensive range of products for your research purposes. We are pleased to present our latest product additions, which include two N-terminal-derived peptides of Annexin A1, the somatostatin analog Vapreotide, the GP IIb/IIIa receptor antagonist Ep

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22 April 2009

Peptide and protein toxins are widespread in the animal kingdom as well as in microorganisms and fungi.Their unique properties make them valuable tools in various areas of research. The conotoxins produced by marine snails can target receptors on sodium or calcium channels depending on their stru

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22 April 2009

Bachem has announced that at the annual general meeting of Bachem Holding on 22 April 2009 Dr Jürgen Brokatzky-Geiger was elected as a new member of the board of directors by a vast majority. He will replace Dr François L'Eplattenier, who retires due to the age limit. Dr J

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1 April 2009

Bachem and Debiopharm has announced the conclusion of a follow-up agreement for the long-term supply of Triptorelin Pamoate. Bachem has been supplying Triptorelin Pamoate, the active ingredient for Debiopharm’s Decapeptyl® (Trelstar® in the USA), for the treatment of prostate cancer,

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12 March 2009

In the business year 2008 the Bachem Group achieved sales of CHF195 million. Compared with the previous year, this corresponds to a 2% sales growth in local currencies or a 1.7% sales decline in CHF. The negative foreign currency impact is due in particular to the weaker US dollar, which lost

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16 September 2008

Bachem announced today that Dr. Lester Mills will become the fourth member of the company’s Corporate Executive Committee on 1 January 2009. Lester Mills will be responsible for global marketing and sales, and will strengthen the existing team of Rolf Nyfeler, chief executive officer, Daniel Er

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15 April 2008

Sales grow to CHF198.3 million – up 17.0% in local currencies and 15.5% in CHF respectively Operating profit up 29.9%, net income up 37% Operating margin rises sharply to 36.5%, net income margin now at 32.3% Prosposed increase in dividend by 50% to CHF3.00 pe

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15 April 2008

Action Pharma A/S and Bachem (SWX: BANB) today announced their cooperation on AP214, Action Pharma’s lead compound, about to enter Phase 2 clinical trials in post-surgical organ failure. Since 2002, Bachem has supported Action Pharma by producing the peptide active ingredient of this drug candid

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6 February 2008

Bachem announced today that the Japanese Ministry of Health, Labour and Welfare (MHLW) has granted the company a manufacturing license in conformity with the new regulations. The license is granted for the manufacture of active pharmaceutical ingredients (APIs) for the Japanese market at Bachem'

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Regional Offices

Bachem (UK) Ltd

Delph Court

Sherdley Business Park

Merseyside

Sullivans Way, St. Helens

WA9 5GL

Other

United Kingdom

+44 1744 61 2108 +44 1744 73 0064
Peninsula Laboratories, Inc.

305 Old County Road

San Carlos

California

94070

Other

United States of America

+1 650 592 5392 +1 650 595 4069
Bachem Americas

3132 Kashiwa Street

Torrance

California

90505

Other

United States of America

+1 310 539 4171 +1 310 530 1571
Bachem Bioscience, Inc.

3700 Horizon Drive

King of Prussia

Pennslyvania

19406

Other

United States of America

+1 610 239 0300 +1 610 239 0800
Sochinaz SA

Route du Simplon 22

1895 Vionnaz

Other

Switzerland

+41 24 482 4444 +41 24 482 4445
Bachem Distribution Services GmbH

Hegenheimer Strasse 5

79576 Weil am Rhein

Other

Germany

+41 61 935 2323 +41 61 935 2325
Bachem AG

Hauptstrasse 144

CH-4416 Bubendorf

Other

Switzerland

+41 61 935 2333 +41 61 935 2325 Online Catalogue www.bachem.com

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