TriMen Chemicals - Custom Research and Synthesis

With nine years of experience in organic synthesis and medicinal chemistry, TriMen Chemicals assists its clients in shortening the time and lowering the cost of the early stages of the drug discovery process. Our objective is to create a long-term relationship with our customers by supplying excellent value-for-money services.

LABORATORY-SCALE DRUG AND CHEMICAL SYNTHESIS

To help our partners in their drug discovery and chemical development efforts, TriMen provides custom synthesis of compounds for multiple drug discovery applications. TriMen personnel provide extensive experience in synthesis, synthetic route design, and execution. TriMen staff members offer a variety of services, including:

• Synthesis on milligram to 50g+ scale
• Execution of the established synthetic routes, design of new synthetic routes, troubleshooting of existing synthetic routes, optimisation of synthetic routes for scale up to support pre-clinical leads
• Synthesis of lead compounds, intermediates and reference compounds
• Synthesis of metabolites or standards
• Synthesis of analogue libraries

TriMen offers laboratory-scale synthesis and medicinal chemistry services (from milligrams to grams). Our research model favours a problem-solving and project-management approach, which focuses on client deliverables. Typical projects are research-oriented and require a multi-step organic synthesis. We have the ability to exercise an existing synthesis, or design a new synthesis when there is no developed chemical plan.

We work quickly and efficiently while maintaining full confidentiality regarding our clients' intellectual property. We provide complete documentation and support according to each specific customer’s requirements.

TriMen Chemicals possesses the state-of-the-art analytical equipment necessary for successful accomplishment of the custom synthesis and small-molecule medicinal chemistry projects:

• LC-MS Waters chromatogram with a detection of molecular mass up to 2,500 Daltons
• Bruker 500MHz NMR spectrometer (optionally, TriMen has an access to the 700MHz apparatus)
• Preparative HPLC allowing for purification of small amounts of polar compounds when the very high purity of the compound is required

ADVAMACS CATALOGUE OF UNUSUAL AMINO ACIDS

Optimisation of the lead structure is an important stage of each and every medicinal chemistry project. Understanding the ever-increasing demand for the molecular diversity elements and capitalising on the unique know-how developed especially in the field of amino acid chemistry, TriMen Chemicals has created a new brand dedicated to the catalogue sale of unusual amino acids called Advamacs. The name of this brand is derived from advanced amino acids and the product categories offered at the moment include:

• β-2-substituted amino acids
• β-3-substituted amino acids
• α-disubstituted amino acids
• N-methyl amino acids
• Amino alcohols

New classes of building blocks and molecular diversity elements are continuously introduced to our catalogue.