The usefulness of LC/MS/MS methods for the unambiguous identification and quantification of pesticides in complex matrix samples is well known. Especially triple quadrupole systems have proven to be useful for this task due to their high specificity in MS/MS mode and their low detection limits. However, working in MS/MS mode makes any MS system blind for all other compounds than the current MS/MS transition is designed for. Therefore, it is difficult to develop methods for simultaneous analysis of high numbers of pesticides. Thus, other ways of achieving specificity are of interest, such as the high mass accuracy and mass resolution of an ESI-TOF system. It can generate high specificity without limiting the number of simultaneously observed target compounds: Multi-targeting.