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Use of BioExpress® System to Develop Biomarker Profiles for Autoimmune Diseases

Case Study of Multiple Sclerosis

Autoimmune disorders are a complex set of debilitating, systemic diseases that affect 8% of the population of the United States or about 20 million people. To place their prevalence in perspective, autoimmune diseases occur in twice as many people as cancer in the United States and are the fourth highest cause of disability among women. They may involve virtually any tissue or organ and present with a vast array of signs and symptoms, manifesting as multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriasis, Crohn’s disease, Hashimoto’s thyroiditis and many others. The underlying, common theme of autoimmune diseases is inappropriate attack by the immune system against the host due to a breakdown in the safeguard of immune tolerance. Strategies to manage autoimmune diseases have been aimed at control of self-reactive immune cells, the regulatory cells that govern self-reactive T cells, at immune mediators such as chemokines and cell trafficking.

This whitepaper outlines the use of the BioExpress® to develop biomarker profiles for autoimmune diseases. A multiple sclerosis case study is provided.

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