New WhitePapers information at Drug Development Technology New and updated information from WhitePapers listed on en-us New WhitePapers information at Drug Development Technology Studying Biophysical Applications of Calorimetric Methods Under specific physiological conditions, unfolded proteins fold into thermodynamically favourable native structures to gain function. Thu, 25 May 2017 08:03:00 GMT Analysing Polysaccharides Using OMNISEC Malvern notes how moving to multi-detector gel permeation chromatography (GPC) or size-exclusion chromatography (SEC) can provide greater insight than conventional measurements. Tue, 16 May 2017 14:59:00 GMT Application: Operating Reactor Systems for Process Research and Development In this case study, three reactor systems (FlexyCUBE 70ml, FlexyPAT 2l, and ChemTeacktor 25l) are operated on the same PC using application software FlexySys. Fri, 12 May 2017 09:37:00 GMT Paradigm Shift Regarding API and Formulation Components This whitepaper will provide an introduction to high-purity carbohydrates often used for applications such as stabilisation, modulation, and cryopreservation, comparing the old paradigm that formulation components are inactive ingredients with limite… Thu, 11 May 2017 15:23:00 GMT Optimising Development Resources for Efficient Product Development Development departments suffer from a shortage of resources and are often overburdened with administration tasks. Thu, 11 May 2017 15:22:00 GMT Top 10 Factors When Choosing a DLS Instrument The physical components and features of a dynamic light scattering (DLS) instrument, along with the instrument's technical specifications, are important when purchasing a new system. Thu, 11 May 2017 15:03:00 GMT ePAT Automated Lab Reactor Optimised for 24/7 Data Capture Systag Systems presents ePAT, a cost-effective device for automation in the laboratory. Tue, 09 May 2017 15:38:00 GMT Characterisation Information of Critical Excipients for Sourcing Critical Raw Materials The increasing complexity of large molecule and cell-based therapeutics calls for an evolution in our understanding of the impurity and functional contributions of each formulation component. Thu, 04 May 2017 15:37:00 GMT Utilising GPC / SEC to Fine-Tune Physical properties of Synthetic Polymers To help develop synthetic polymers, researchers mix two or more types of monomers to impart unique physical properties. Tue, 02 May 2017 09:36:00 GMT Determining Characterisations of Biopharmaceutical Stability with DSC An important parameter in production, manufacturing, formulation, and long-term storage, protein stability has large effects on biopharmaceutical products and higher stability means for greater profits and less product waste. Sun, 23 Apr 2017 23:00:00 GMT Benefits of Trehalose Products such as monoclonal antibodies (mAb), fusion proteins, peptides, vaccines, antibody drug conjugulates (ADC) and stem cells benefit from the stabilising effects of Trehalose. Fri, 21 Apr 2017 15:28:00 GMT Gamlen Study: Breaking Anisotropic Rod-Shaped Particles Gamlen presents a study conducted by V. Penkavova1, L. Kulaviak1, M.C. Ruzicka1, M. Puncochar, and P. Zamostny on the 'Beaking of Anisotropic Rod-Saped Particles'. Tue, 18 Apr 2017 23:00:00 GMT Reasons to Upgrade to a MicroCal PEAQ-DSC System Differential Scanning Calorimetry (DSC) is a tool for protein stability characterisation in drug development. Its data is used to advance stable and developable proteins into the pipeline, while optimising process and formulation conditions to mainta… Sun, 16 Apr 2017 23:00:00 GMT Case Study: Compaction Behaviour of Orally Dispersable Mini-Tablets This whitepaper describes a method for performing dynamic powder compaction analysis and for measuring tensile fracture strength of tablets. Wed, 12 Apr 2017 09:02:00 GMT Processability Assessment of Crystal Habit-Modified Active Pharmaceutical Ingredients The efficiency of downstream processing of active pharmaceutical ingredients (API) can depend on their particulate properties, including size and shape. Thu, 06 Apr 2017 09:44:00 GMT Validated Metal Analysis Four commonly utilized carbohydrates for ptotein stabilization are Sucrose, Trehalose, Mannitol, and Maltose. Thu, 30 Mar 2017 15:45:00 GMT Improving OMNISEC Results by Switching Mobile Phases Polylactic and polyglycolic acid are used for a number of applications including biomedical applications. Absorbable sutures, medical implant hardware, food packaging, and clothing all utilise these chemicals, which can also be used as a feedstock ma… Mon, 27 Mar 2017 08:00:00 GMT Orthotopic and metastasis models for preclinical efficacy testing of novel cancer drugs Lack of efficacy is one of the major causes of attrition in the clinical development of new compounds to treat cancer. Fri, 03 Mar 2017 12:00:00 GMT How Investing in Malvern Instruments Helped KBI Biopharma Find a Clear Commercial Advantage Differing sample matrices and presentation can create various challenges, not least for KBI's technology platforms, which often require specialised methods and application experts in order to optimise the quality of the data they collect. Thu, 23 Feb 2017 15:00:00 GMT Softigel by Procaps Brochure Procaps is one of the world's largest softgel companies, specialising in the production and development of advanced gelatin-related technologies. Fri, 20 Jan 2017 16:50:00 GMT