Malvern Panalytical Biopharmaceutical and Drug Development

Characterisation technologies

Malvern Panalytical offers characterisation tools for molecular analysis and small drug discovery to help accelerate development for the pharmaceutical industry.

Malvern Panalytical provides characterisation technologies to the drug development industry that advance production processes by increasing productivity and yielding high-quality products at short time-to-market.

The company’s portfolio features a range of automated analysis tools and systems that provide information on key attributes such as particle size, shape, chemical identity, molecular weight, size, and concentration.

These reliable and robust characterisation techniques help drug development companies predict how a product will perform during use and allow for optimisation.

Systems for critical material attribute information

Malvern Panalytical has a wide range of experience in small molecule pharmaceuticals.

Services include systems that provide information on variables identified as critical material attributes (CMA) such as particle size, shape and chemical identity, or molecular weight and size.

Whether characterising particle size and morphological properties of a novel active pharmaceutical ingredient (API) or rheological attributes of a new chemical entity (NCE), Malvern Panalytical can achieve efficiency using common platform technologies.

Small molecule drug discovery and development

Malvern Panalytical’s range of analytical solutions focuses on testing and manufacturing requirements, while taking into account time and cost pressures, as well as sample availability and complexity.

Label-free technologies appeal to researchers across various applications, including biological research, biotherapeutic and small molecule drug discovery and development, immunogenicity studies, vaccine development and quality control.

Label-free techniques are used in the direct study of native molecules, and generate biologically relevant data enabling understanding of molecular interactions without using artificial probes or labels.

Isothermal titration calorimetry for biomolecular interactions

Malvern Panalytical’s MicroCal range includes isothermal titration calorimetry (ITC) and differential scanning calorimetry (DSC).

ITC is used in quantitative studies of a range of biomolecular interactions, that work by directly measuring heat that is either released or absorbed during a biomolecular binding event.

By providing a complete thermodynamic profile of the molecular interaction, ITC can explain mechanisms’ underlying interactions, and enable more confident decision-making in hit selection and lead optimisation.

DSC is used to characterise stability of a protein or other biomolecules directly in its native form, and achieves this by measuring heat change associated with the molecule’s thermal denaturation.

Precise and high-quality data obtained from DSC provides vital information on protein stability in process development, and in the formulation of potential therapeutic candidates.

Size exclusion chromatography systems for assessment of product purity

Malvern Panalytical’s analytical toolbox for biopharmaceutical development is tailored to provide trusted solutions such as OMNISEC size exclusion chromatography systems to assess product purity.

The Zetasizer range is also available for sizing and zeta potential analysis for product stability.

The company’s Archimedes and NanoSight systems quantify early aggregation in bioformulations.

About Malvern Panalytical

Malvern Panalytical’s technical experts are available to support and work with researchers to find the right solution for individual challenges.

Providing agile technology development in partnership with its Bioscience Development Initiative, Malvern Panalytical is always looking for new solutions to enable quicker, easier and more useful analysis.

The company has a suite of instruments that provides access to biophysical information focused on accelerating through characterisation studies, formulation development and quality control.

Malvern Panalytical provides high-quality products and helps clients to achieve maximum return from investment.

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Press Release

Malvern Panalytical to Host Seminars in September and October

Malvern has announced a series of seminars taking place throughout September and October. If you are interested in attending any of the events and have any questions, please make an enquiry using the form on this page.

White Papers

Quick and Flexible Elemental Screening with Omnian

Omnian was developed for Malvern Panalytical's high-end x-ray fluorescence (XRD) spectrometer and is also available for the Epsilon 4 energy dispersive x-ray fluorescence (EDXRF) benchtop systems. This powerful combination brings together the strengths of Omnian with the ease-of-use of Epsilon 4.

Malvern Panalytical Images

Products and Services

MicroCal DSC Range for Characterisation of Thermal Stability

The MicroCal DSC range contains two high-quality MicroCal PEAQ-DSC microcalorimeters designed for analysis for the regulated environment. These powerful devices enable the characterisation of thermal stability for proteins and other biomolecules, primarily for biopharmaceutical development and manufacture.

MicroCal PEAQ-DSC Manual for Stability Testing

The MicroCal PEAQ-DSC system offers sensitive, simple microcalorimetry for time and cost-effective stability testing and comparability analysis.

Viscotek UV Detector for Measuring Polymers and Proteins

Viscotek UV detector provides accurate measurements of the polymer or protein concentration profile that is essential to good molecular weight or structure data.

Zetasizer AT for Dynamic Light Scattering

Malvern's Zetasizer AT brings the industry leading Dynamic Light Scattering (DLS) technology of the Zetasizer Nano to the process development and manufacturing arena, enabling real time monitoring of nanoscale particle processes online.

Malvern Viscosizer TD with Taylor Dispersion Analysis

Malvern Viscosizer TD uses Taylor dispersion analysis for automated biophysical characterization.

MicroCal PEAQ-DSC Automated for Protein Stability Analysis

MicroCal PEAQ-DSC Automated is a high-quality protein stability analysis instrument, designed for the regulated environment. This system delivers high-throughput, sensitive protein stability analysis, with low-sample consumption, in an automated, integrated platform for increased productivity.

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Press Release

12 September 2018

Malvern has announced a series of seminars taking place throughout September and October. If you are interested in attending any of the events and have any questions, please make an enquiry using the form on this page.

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30 August 2018

Malvern Panalytical has announced a wide range of webinars it will be hosting in September and October.

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7 August 2018

Liposomes are nowadays frequently used as drug delivery systems, and as such requires that they are well characterised for manufacturing and batch release. This characterisation includes their size and size distribution.

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31 July 2018

For virus development and production, it is important to know the virus concentration at different stages of the process, to optimise the clone used and the production yields.

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27 July 2018

Malvern Panalytical will be hosting a range of new webinars and seminars in August and September.

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9 July 2018

Malvern Panalytical has announced a wide range of upcoming webinars throughout July, including ‘Enter a New Dimension of X-Ray Diffraction Analysis’ and ‘Applications of Light Scattering and Intrinsic Viscosity Detectors with Size Exclusion Chromatography SEC in Characterising Biopharmaceutical and Other Polymers’. To register for any of these webinars, please either make an enquiry using the form on this page or visit www.malvernpanalytical.com/en/learn/events-and-training/webinars.

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3 July 2018

This year’s European Powder Diffraction Conference (EPDIC16) is the stage for Malvern Panalytical’s new Empyrean platform, an instrument that redefines the concept of multipurpose X-ray diffraction.

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13 June 2018

Malvern Panalytical has organised a range of seminars such as ‘One-on-One Breakfast Catch-up on the Latest Powder XRD’ and ‘XRF Demonstration (Singapore)’.

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6 June 2018

Malvern Panalytical will be hosting ‘A Basic Introduction to Rheology and Rheometry – Part Two, Viscoelectricity’ and ‘Enter a New Dimension of X-ray Diffraction Analysis’ webinars this month.

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23 May 2018

Malvern Panalytical has announced two new additions to its Zetasizer range, the Zetasizer® Pro and Ultra systems.

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3 May 2018

Malvern Panalytical will be hosting a number of webinars in May.

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13 April 2018

Malvern Panalytical has announced three upcoming webinars in April.

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14 February 2018

Malvern Panalytical has announced its new high-definition particle imaging and characterisation solution. The Morphologi® range of automated static imaging systems includes the Morphologi 4 and Morphologi 4-ID.

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2 February 2018

Malvern has announced it will be holding a new webinar to explain the use of electrophoretic light scattering (ELS) to measure the electrophoretic mobility of particles or molecules in a solution.

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31 January 2018

Malvern Panalytical has announced the introduction of the new high-performance Epsilon 4 Benchtop XRF Spectrometer for the determination of the chemical composition of materials.

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25 January 2018

Sometimes referred to as photon correlation spectroscopy or quasi-elastic light scattering, dynamic light scattering (DLS) is a technique classically used for measuring the size of particles typically in the sub-micron region, dispersed in a liquid.

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19 January 2018

Malvern Panalytical has announced a new webinar ‘Characterising Liposome Formation, Structure and Stability with Complementary Techniques’ that will take place this month.

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11 December 2017

Malvern has announced that it will be presenting webinar 'An Orthogonal Approach for Complex Drug Characterization'.

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4 December 2017

Malvern Panalytical has announced the launch of a collaborative project that aims to support the development of existing and next generation biopharmaceutical products.

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6 September 2017

Malvern will be hosting a wide range of webinars throughout September and October

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18 July 2017

Supplier of analytical X-ray instrumentation and software PANalytical has announced the introduction of a new Epsilon 1 X-ray fluorescence (XRF) spectrometer.

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11 July 2017

Understanding the make-up of crystalline structures is a vital aspect of the characterisation of new compounds, and can be regarded as an important first step towards the possibility of tailoring its properties.

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26 April 2017

Malvern has announced it will be hosting a new webinar presenting size-exclusion chromatography (SEC) data and discussing the impact of different formulations and external stress conditions on Monoclonal antibodies and biosimilar molecules.

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6 April 2017

Malvern has announced it will host a new webinar discussing the difference between rheometers and viscometer to help viewers decide which of the two is most suitable for their application.

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7 March 2017

Malvern is hosting two webinars this month: Differential scanning calorimetry (robust and powerful physical characterisation of therapeutic protein products) and Cement (composition, structure, and fineness - we are stronger together!).

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20 February 2017

Efficiency of the production process of powder bed additives is reliant on packing density and flow behaviour of metal powders involved.

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17 February 2017

Malvern has announced it will be unveiling its new protein stability characterisation product for regulated environments MicroCal PEAQ-DSC in an upcoming webinar.

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14 February 2017

Malvern has announced that it will be presenting a webinar on the basic principles of particle size analysis.

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6 February 2017

Malvern has announced it will present a webinar discussing the particle tracking analysis (PTA) method (ISO19430) and what it means for nanoparticle measurements.

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1 February 2017

If you are attending Pittcon this year, you can register for Malvern's short courses, which are taught by recognised characterisation experts.

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23 January 2017

Malvern has announced it will be presenting a webinar discussing the use of laser diffraction as a technique in characterising nebulisers and how it is helpful in understanding the delivery of the drug product.

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11 January 2017

Size exclusion chromatography (SEC) is a popular analytical technique for studying protein molecular weight, oligomeric state, aggregation, and conjugation.

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12 December 2016

Malvern has announced it will host a live-panel webinar for the discussion of challenges submitted in an online form on the company's website.

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5 December 2016
24 November 2016

Malvern has announced its latest webinar discussing the types of technologies used for analysing particulates in injectable drugs.

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9 November 2016

Advancements in portable electronic devices such as mobile phones and laptops has increased demand for advances in battery technology.

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8 November 2016

Malvern has announced it will host a webinar discussing the use of a diffusion interaction parameter (kD) measurement for the Taylor dispersion analysis in early stages of development.

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3 November 2016

Malvern will be hosting a webinar to discuss the rheological requirements of paintings and coatings, as well as how they can be measured using a rotational rheometer.

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10 October 2016

Malvern has announced it will be demonstrating the NanoSight NS3000, which uses Nanoparticle Tracking Analysis (NTA) to measure nanoparticles and concentrates.

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8 September 2016

Cosmetics, paints, inks, paper, drug delivery, personal care, food or intra-lipid emulsions are made up of multi component chemistries. Most products go through a stage where different phases co-exist such as emulsions, suspensions or dispersions and as such require a specific amount of stability in order to meet expected performance criteria.

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18 August 2016

Key data for the approval of a nasal spray containing mometasone furoate has been obtained by the Food and Drug Administration (FDA) through the use of Malvern's Morphologi G3-ID system.

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7 June 2016

Malvern Instruments has launched the new Zetasizer AT, a robust, online, automated analyzer that uses dynamic light scattering (DLS) to automatically measure the size of nanoparticles in suspensions and emulsions.

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7 March 2016

Malvern will be hosting a webinar on 8 March at 10:30AM EDT.

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4 March 2016

Researchers working on the European Metrology Research Project NanoChOp (Chemical and Optical Characterisation of Nanomaterials in Biological Systems), funded by EURAMET, have concluded the NanoSight Nanoparticle Tracking Analysis system offers a unique insight into the behaviour of nanoparticles in biological systems.

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11 December 2015

The latest software release and expansion of the global technical specialist team highlight Malvern Instruments' ongoing commitment to extending and supporting the application of NanoSight, a nanoparticle characterisation technology with unique capabilities.

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3 December 2015

A collaboration between Malvern Instruments and Bio-Rad from Hercules, California has delivered new analytical tools for the rapid identification of unknown particles.

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2 November 2015

Insights shared by Particle Characterization Laboratories director William Bernt highlights the impact of adding a Malvern NanoSight nanoparticle tracking analysis (NTA) system to the toolkit for nanoparticles.

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14 October 2015

New tools from Malvern that address specific analytical challenges in biopharma development will be at the AAPS Annual Meeting and Exposition 2015, in Orlando, US.

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24 September 2015

Insight from CP Kelco, a global leader in the specialty hydrocolloids market, provides a blueprint for the intelligent, cost-efficient deployment of gel permeation/size exclusion chromatography (GPC/SEC) in biopolymer manufacture.

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19 September 2015

Malvern has established a new biopharmaceutical applications laboratory in the heart of San Diego's biotechnology cluster.

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18 September 2015

Malvern Instruments has launched an improved rSolution platform on their Kinexus rotational rheometer.

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