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Processability Assessment of Crystal Habit-Modified Active Pharmaceutical Ingredients

The efficiency of downstream processing of active pharmaceutical ingredients (API) can depend on their particulate properties, including size and shape. Flowability and tabletability issues may be especially prominant in drug products with high API content, such as a crystal habit of an API. However, these can be adapted to the needs of downstream processing. Gamlen modified the needle-like crystal habits pf 5-ASA through direct compression using ring sheer testers, flow rate analysers, and instrumental tablet press. Find out more about this case study, including the experiment results and powder and flow property assessments, download this free whitepaper.

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