Malvern Viscosizer TD uses Taylor dispersion analysis for automated biophysical characterization.
The tool provides ultra-low volume, solution-based molecular size and stability measurement capabilities.
The device also uses Poiseuille flow for relative viscosity assessment.
Viscosizer TD provides an orthogonal technique for conformational stability analysis to extend into label-free measurements in highly complex solutions, and encompasses a critical size range from small molecules through to protein-based systems.
Viscosizer TD features UV area imaging in microcapillary flow for ultra-low volume biophysical characterization of target biomolecules in solution.
Taylor dispersion analysis is a simple experimental method, where a nanoliter volume sample pulse is injected into a laminar flow of matched buffer.
Analysis of the time-evolved concentration profile, or Taylorgram, from UV absorption allows the molecular diffusion coefficient and hydrodynamic radius of solute molecules to be determined.
Viscosizer TD uses fully automated methodology to analyze stability of small molecules, peptides, proteins and samples with mixtures of these species in the presence of excipients and surfactants that can interfere in other techniques.
Microcapillary flow methodology allows complementary relative viscosity measurement on the same sample using Poiseuille’s law.